Tuberculosis: the use of clay minerals nanoparticles to leverage isoniazid treatment efficiency, a promising future

Abstract

Tuberculosis is a globally widespread infectious disease with elevated
transmissibility and expressive mortality rate. It affects people throughout all age groups
causing a strong economic impact on public health systems. Isoniazid, which was
launched in the market in the 60’s, has been the most effective antimicrobial drug for the
treatment of tuberculosis so far. However, this is a long treatment with many adverse
effects resulting in poor patient compliance. Therefore, it is necessary to develop oral
intake systems that minimize the adverse effects of the drug to guarantee patients
adherence to the treatment. Over the last decade, extensive research has shown that the
development of controlled release systems is an effective way of addressing isoniazid’s
adverse effects. The intercalation of isoniazid in clay minerals such as bentonites present
highly promising results and accounts for one of the uttermost contributions of material
engineering science to human medicine. The present study review seeks to summarize
and allow readers to understand the most recent researches on this subject.