Analysis of excipients used in capsules prepared in magistral pharmacies of the Baixada Fluminense-RJ
Keywords:
Excipients, Capsules, Magistral PharmacyAbstract
Magistral pharmacies currently represent an important segment in the Brazilian drug market. It is known that in magistral preparations, drugs are associated with excipients, which are substances that have different characteristics and functions, helping in pharmaceutical formulations. The inappropriate use of these adjuvants can cause interactions with the drug and thus compromise its bioavailability and therapeutic efficacy. Based on this fact, the objective of this work was to evaluate the excipients used in magistral preparations, in the pharmaceutical form of capsules, in magistral pharmacies in Baixada Fluminense-RJ. Data collection was carried out through a questionnaire that was filled out by the pharmacist responsible for each researched establishment, to which the excipient used for the preparation of each mentioned drug was selected. Based on the results exposed in the present study, it was concluded that there is a high error rate in the selection of excipients used in the evaluated formulations of the main manipulated drugs, highlighting the use of adjuvants that have incompatibilities with the analyzed drugs. Considering that most medications, being Fluoxetine, Losartan, Risperidone, Tadalafil, Atenolol, Enalapril, Clonazepam and Hydrochlorothiazide, are widely prescribed, it is necessary to give due importance to the formulations, to guarantee the safety and quality of the magistral products.
