Evaluation of stress and anxiety in mice with colorectal cancer submitted to physical exercise
Keywords:
Models, Animals, Neoplasms Associated with Colitis, Elevated cross maze test, ExerciseAbstract
Purpose:To evaluate the effect of physical exercise on the behavior of rodents with colorectal cancer induced by using the elevated cross maze. Methods:Forty male hairless mice induced colorectal cancer were used, divided into five groups: G1) submitted to pre- and post-induction swimming; G2) pre- and post-induction stairway; G3) post-induction swimming; G4) post-induction stairway; G5) sedentary. At the end of the 14th week, the animals were subjected to the cross maze test.Results: The mean dwell time in the open arm for G1 was 4.17±6.50; G2 37.52±40.7; G3 85.84±42.5; G4 32.92±23.17; and G5 4.09±4.43. In the closed arm, they were 264±23.43 in G1, 187.60±47.73 in G2, 147.50±40.03 in G3, 182.00±40.40 in G4, and in G5 235.36±14.28. In the center, G1 got 31.86±20.18, G2 74.85± 28.37, G3 66.69±19.53, G4 60.55±10.46, and G5 60.55±23.65. Conclusion: Aerobic exercise for seven weeks after tumor induction had less impact on animal behavior. On the other hand, it significantly increased the stress level of the animals when applied for 14 weeks before and after tumor induction.
