Vitamin D: A New Anti-Asthma Agent? - Literature review

Abstract

According to Cotran; Kumar and Robbins (2015), the pathophysiology of asthma is characterized by two reactions, immediate and late, but also by the production of interleukin (IL) 4, IL-5 and IL-13 by Th2 lymphocytes, thus IL-4 and IL -13 are responsible for inducing the expression of IgE by B lymphocytes, in addition, IL-13 also acts by increasing the production of mucus in the airways and IL-5 acts on the differentiation and activation of eosinophils. Thus, in the immediate phase, degranulation of mast cells occurs through IgE, with subsequent release of histamine and Leukotrienes (LT) C4 and D4. In the late phase, the recruitment of more inflammatory cells such as Th2 lymphocytes and eosinophils is observed.

DOI:https://doi.org/10.56238/sevenIVmulti2023-109